ACE and Hypertension: Another important and frequent AE is hypertension, which, in some patients, is easily managed with medical monotherapy, in particular by the use of angiotensin-converting enzyme (ACE) inhibitors (which have a beneficial effect on proteinuria, too), while other cases requires the use of multiple drugs to be controlled (e.g., calcium channel blockers or sartanics or diuretics) (36).