Another important and frequent AE is hypertension, which, in some patients, is easily managed with medical monotherapy, in particular by the use of angiotensin-converting enzyme (ACE) inhibitors (which have a beneficial effect on proteinuria, too), while other cases requires the use of multiple drugs to be controlled (e.g., calcium channel blockers or sartanics or diuretics) (36). The gene discussed is ACE; the disease is hypertensive disorder.