The authors further showed PLK2 promotes tumour growth and inhibits apoptosis of CRC cells in vitro and in vivo by binding to FBXW7 and subsequently promoting its degradation, which in turn leads to the stabilization of Cyclin E, similar to our previous finding that FBXW7 mutations seemed to be associated with radioresistance (13). This evidence concerns the gene CCNE1 and neoplasm.