Among them, MMP9 regulates cell–cell adhesion by catalyzing E-cadherin ectodomain shedding to mediate metastatic dissemination, whereas MMP2 mediates the peritoneal adhesion of ovarian cancer cells by cleaving the extracellular matrix proteins fibronectin and vitronectin into small fragments (28, 29). The gene discussed is FN1; the disease is ovarian carcinoma.