Among them, MMP9 regulates cell–cell adhesion by catalyzing E-cadherin ectodomain shedding to mediate metastatic dissemination, whereas MMP2 mediates the peritoneal adhesion of ovarian cancer cells by cleaving the extracellular matrix proteins fibronectin and vitronectin into small fragments (28, 29). This evidence concerns the gene MMP9 and ovarian cancer.