Consistent with previous reports (17, 18), PDIA1 and PDIA3 were overexpressed in colon cancer tissues in comparison with that in their adjacent tissues, in addition to the overexpressed PDIA2; however, no statistic changes were detected for PDIA4, PDIA5, and PDIA6 expression (Supplementary Figure S7). This evidence concerns the gene P4HB and malignant colon neoplasm.