KPNA2 and metastatic malignant neoplasm in the lymph nodes: As shown in Figures 1D–I, elevated KPNA2 levels markedly correlated with tumor invasion depth (P = 0.03092) and histological grade (P = 0.02234), however, no significant correlation was observed with lymph node metastasis (P = 0.3849), gender (P = 0.9542) and age (P = 0.3158).