In TSCC tumor tissues, activated mast cells (P = 0.0044), plasma cells (P = 0.0005) and naive T cells CD4 (P = 0.0474) were highly infiltrated in high KPNA2 group, while naive B cells (P = 0.0080), resting mast cells (P = 0.0021), helper T cells follicular (P = 0.0164) and regulatory T cells (P = 0.0010) were all significantly enriched in the low KPNA2 group (Figure 2A). The gene discussed is CD4; the disease is neoplasm.