FKBP51 is believed to serve as a scaffolding protein that recruits PHLPP to Akt to facilitate dephosphorylation in pancreatic cancer and endometrial adenocarcinomas (15, 21, 22).In this study, we found FKBP51 downregulated is related to Ara-C resistance in AML-M5. This evidence concerns the gene PHLPP1 and acute myeloid leukemia.