GMFB and cancer: The present study employed The Cancer Genome Atlas (TCGA) database and the CIBERSORTx tool (https://cibersortx.stanford.edu) to explore the potential effects of GMFB and GMFB-related TME, and the significant findings of molecular signatures were confirmed by quantitative real-time PCR (qRT-PCR), Western blotting, and immunostaining in human renal clear cell carcinoma cell line Caki-2.