In the SCLC plasma cohort, the top three downregulated genes in the fold change (FC) were early growth response 1 (EGR1), complement factor D (CFD) and FosB proto-oncogene AP-1 transcription factor subunit (FOSB), while the top three upregulated genes in FC were zinc finger protein 704 (ZNF704), NOVA alternative splicing regulator 1 (NOVA1) and attractin like 1 (ATRNL1) (Table 2). This evidence concerns the gene CFD and small cell lung carcinoma.