LCIIAR and lung cancer: As expected, LCIIAR knockdown inhibited LUAD cells proliferation and colony formation (Figures 8D–G). Next, we confirmed that knockdown of LCIIAR inhibited LUAD cell migration examined by trans-well assays (Figures 8H, I). To investigate whether LCIIAR-mediated lung cancer proliferation and migration are dependent on its hypo-methylation, we conducted the rescue experiment and found that 5Aza treat could overcome the cellular effect resulted from LCIIAR knockdown on the LUAD cell proliferation and migration (Figures 8J–L).