Thus, using viSNE, we corroborated that cTreg cells (Foxp3+) and Tr1 cells (Foxp3−CD49b+) conform to two separate and distinct populations inside the CD4+ T cell subset present in the lymph nodes of naive and tumor mice (nLN, TdLN) and in the TILs fraction, which can be identified by their Foxp3GFP and CD49b expression (Figure 3D). The gene discussed is ITGA2; the disease is neoplasm.