Moreover, with the objective of interrupting Tr1 cells in tumors, we administered anti-CD29 antibody into tumor-bearing animals, which resulted in a dramatic impairment of tumor growth accompanied by an increased presence of IFN-γ+ cTreg and IFN-γ+ Tr1 cells with reduced expression of IL-10, in addition to an increase in IFN-γ+CD4+T cells (Th1) and IFN-γ+CD8+T cells (cytotoxic T cells or Tc). Here, IL10 is linked to neoplasm.