One study confirmed that after treating A549, H358, H460 and LLC cells with hypoxic BMSC-EVs, hypoxic BMSC-EVs could transfer miR-193a-3p, miR-210-3p and microRNA-5100 into lung cancer cells and activate STAT3-induced EMT, thereby promoting metastasis of lung cancer cells (44). This evidence concerns the gene STAT3 and lung cancer.