first confirmed that Kruppel-like factor 15 (KLF15) was a target gene of miR-190a-5p using dual-luciferase reporter gene assay, and then detected miR-190a-5p by qRT-PCR and Western blotting the expression regulation of KLF15 and the effect of BMSC-EVs on the migration and invasion of lung cancer cells (A549, LK79, H1975 and HCC827) were detected by Transwell assay. This evidence concerns the gene KLF15 and lung cancer.