Furthermore, both bishonokiol A and 1, 2-Diarachidonoyl-Sn-glycero-3-phosphoethanolamine (DAPE) upregulated CypD expression by activating the RIP1/RIP3/MLKL necrosis cascade, thus promoting mPTP-mediated necrosis of breast cancer and malignant pleural mesothelioma cells (75, 76). The gene discussed is PPIF; the disease is breast cancer.