CDH1 and esophageal squamous cell carcinoma: Here, we found that the protein level of E-cadherin was further suppressed by enforced C12orf59 overexpression in the combination of YAP activation, whereas the reduced protein level of E-cadherin resulting from C12orf59 overexpression was abrogated upon YAP inhibition, suggesting YAP inhibits E-cadherin expression in ESCC cells.