Notably, FAT atypical cadherin (FATs) and Ajuba LIM Protein (AJUBA) mutations or Yes-associated protein (YAP) amplification accounted for nearly half of ESCC samples, indicating that dysregulation of the Hippo/YAP signaling could be of great importance for ESCC progression (7–10). Here, AJUBA is linked to esophageal squamous cell carcinoma.