Previous study reported that C12orf59 was normally undetectable in a panel of genitourinary cancer cell lines, and decreased C12orf59 expression was relevant to poor prognosis and von Hippel-Lindau mutations in renal cell carcinoma (RCC), suggesting C12orf59 as a tumor suppressor in RCC (24). This evidence concerns the gene TMEM52B and hereditary clear cell renal cell carcinoma.