CYP2E1 and neoplasm: P1, which constituted a major fraction of HB tumor cells and had the highest C1 group score, exhibited a more mature hepatocyte-like phenotype, expressing the highest level of ALB as well as liver metabolism genes (e.g., CYP2E1, GSTA1, G6PC) (Figures 5C, D; Supplementary Figure S3F) (46).