TOP2A and neoplasm: Functional gene ontology (GO) enrichment analysis indicated that genes with higher expression in SBL PT tumor cells were mainly enriched in cell division (CENPF, TOP2A), cell migration (BST2, NR4A1, KIF2A, TJP1) and negative regulation of cell differentiation (YBX1, EFNB2, DNMT1), supporting that T1 possessed a more malignant and invasive phenotype, which is consistent with gene set enrichment analysis (GSEA) (Figures 3J, K).