IGF2 and neoplasm: An important aspect of BWS diagnostics is childhood tumor prediction since imprinting aberrations in the imprinting center IC1 (also called the H19/IGF2 Differentially Methylated Region, DMR) are associated with high tumor risk whilst those in IC2 (KCNQ1OT1 DMR) are not (Maas et al., 2016; Mussa et al., 2016; Brioude et al., 2018).