KMT2D and Kabuki syndrome: Other examples of genes with multiple signatures are SRCAP (Floating Harbor syndrome and DEHMBA) (Rots et al., 2021), KMT2D (Kabuki syndrome and CHARGE-like phenotype) (Cuvertino et al., 2020) and KAT6B (GTPTS and SBBYSS) (Aref-Eshghi et al., 2020).