ESR1 and memory impairment: The results of several experiments [21] showed that estrogen can inhibit neuroinflammation and antioxidant and improve memory impairment, and the lignan contained in Sc-At extract belongs to a kind of phytoestrogen, which has the effects of scavenging free radicals in the body, antioxidant, and binding estrogen receptor to interfere with cancer-promoting effects and has a positive effect on AD prevention and treatment; this is similar to the results of our study.