HAMP and acute kidney injury: In AKI, plasma catalytic iron concentrations were significantly increased and correlated with extensive injury caused by cisplatin, ischemia-reperfusion, aminoglycosides, rhabdomyolysis, and hemoglobinuria, and both higher plasma catalytic iron levels and lower hepcidin concentrations were associated with increased mortality in patients with AKI (Leaf et al., 2019).