HA is reflected as one of the main components of the ECM; similarly, it is the foremost ligand for CD44 and RHAMM (Zhong et al., 2016), which are overexpressed in a range of tumor cell surfaces including colon cancer, human breast epithelial cells, lung cancer, and acute leukemia (Zamboni et al., 2017). This evidence concerns the gene CD44 and neoplasm.