CTNND2 and cancer: Aside from its roles in cancer, delta-catenin has been implicated in several genomic studies with potential roles in myopia and malaria resistance, each being diseases where the altered activity of small Rho GTPases has been implicated (Lam et al., 2008; Lu et al., 2011; Atkinson et al., 2012; Yu et al., 2012; Band et al., 2013; Liu and Zhang, 2014; Wang et al., 2014; Mackinnon et al., 2016; Yuan et al., 2018; Paone et al., 2020).