The proteins interacted with “systemic lupus erythematosus” and “alcoholism” pathway centralized in histone family, while the proteins interacted with the other 8 KEGG pathways such as “ErbB signaling pathway” and “long-term potentiation” centralized in CaMKII family (Figure 2(f)). This evidence concerns the gene EGFR and systemic lupus erythematosus.