MAPT and neurodegenerative disease: In neurodegenerative diseases, disease progression is closely linked to microglia activation and systemic inflammation, and the development of AD revolves around Aβ plaques, hyperphosphorylated tau proteins, and microglia, with Aβ and its proinflammatory factors contributing to decreased microglia clearance, and later microglia more likely to interact with Aβ leading to NLRP3 inflammatory vesicle activation, neuronal loss etc. (Hickman et al., 2018).