MAPT and neurodegenerative disease: The main pathological manifestations of neurodegenerative diseases are progressive neurodegeneration and protein amyloid deposition or even pathological proliferation (amyloid includes Aβ, tau proteins and α-systemic nucleoproteins), and these diseases are thought to have a broad relevance to mammalian prions (Heemels, 2016; Zhu et al., 2016).