PSEN1 and Alzheimer disease: To determine whether Cef-induced reversal on recognition memory deficits and suppression on the mGluR2 upregulation in APP/PS1 AD mice were associated with GLT-1 or not, we further investigated the effect of DHK, a selective inhibitor of GLT-1, on the recognition memory and mGluR2 expression after Cef treatment in APP/PS1 mice.