Cef treatment in the dose of 200 and 300 mg/kg significantly inhibited the expression of mGluR2 in APP/PS1 mice represented with weaken immuno-bands (Figure 2B) and decreased IOD of the immunoreactivity (Figure 2C, p = 0.025 and p = 0.001, respectively) in the Cef treatment group compared with APP/PS1 AD mice. This evidence concerns the gene PSEN1 and Alzheimer disease.