Many studies have indicated that Cef could significantly and selectively increase the expression and uptake activity of GLT-1 in vitro and in vivo studies, and this upregulation has shown a beneficial effect in many disease models, such as cerebral neurons in animal models of stroke, oxygen glucose deprivation, and motor neuron degeneration (Rothstein et al., 2005; Liu et al., 2012; Krzyzanowska et al., 2016). This evidence concerns the gene SLC1A2 and stroke disorder.