In the novel object recognition test, the Cef-induced reversal on recognition index in APP/PS1 AD mice was inhibited after the administration of DHK in DHK + Cef group compared with Cef group (Figures 3A,B) [test 1: F(3,53) = 10.503, p < 0.001; test 2: F(3,58) = 4.860, p = 0.004, ANOVA]. The gene discussed is PSEN1; the disease is Alzheimer disease.