The Western blot analysis showed that there was an obviously decrease in the expression of PKA and phosphorylated SNAP25 in APP/PS1 AD mice compared with wild-type mice (Figures 4A,B, p = 0.01 and p = 0.013, respectively) [for PKA: F(3,16) = 6.002, p = 0.006, ANOVA; for phosphorylated SNAP-25: F(3,20) = 4.180, p = 0.019, ANOVA]. The gene discussed is PSEN1; the disease is Alzheimer disease.