So, it might be supposed that in AD model mice, the abnormally activated mGluR2 inhibits cAMP-PKA signal, reduces the phosphorylation of SNAP-25 (Arnsten et al., 2012; Gao et al., 2012), hampers the vesicular fusion with pre-terminal membrane and hence reduces the vesicular glutamate release. This evidence concerns the gene GRM2 and Alzheimer disease.