Extending previous findings of pregnancy-related NK cell changes by exploratory high-dimensional phenotyping, we found a specific subset of CD56bright cells that formed the predominant CD56bright phenotype during pregnancy in MS, and was characterized by a dim expression of the cytotoxicity receptor CD16 and high levels of receptors that regulate cell activity, e.g., NKp46, NKG2D and NKG2A. Here, KLRC1 is linked to myeloid sarcoma.