Compared to the non-PPAP group, male, BMI ≥ 25, preoperative jaundice state, pancreatic duct diameter <5 mm, soft pancreatic texture, the methods of pancreatic anastomosis, and CRP ≥ 180 mg/L were enrolled into the multivariate analysis model for predicting grade B PPAP. This evidence concerns the gene CRP and Polymerase proofreading-related adenomatous polyposis.