The APASL defined ACLF as an acute hepatic insult manifesting as jaundice (serum bilirubin ≥5 mg/dl (85 mmol/L) and coagulopathy (INR ≥ 1.5 or prothrombin activity <40%) complicated within 4 weeks by clinical ascites and/or encephalopathy in a patient with previously diagnosed or undiagnosed chronic liver disease/cirrhosis. This evidence concerns the gene F2 and Cirrhosis.