LENG8 and obesity due to melanocortin 4 receptor deficiency: Interestingly, we found that CCR10, QRFPR, and UHRF1BP1 are upregulated in obesity OA samples compared to normal samples and in obesity OA samples compared to obesity non-OA samples, but LENG8 and HLA-DRB4 are downregulated (Figures 4(a) and 4(b)).