In this study, we analyzed the GSE117999 dataset from the GEO database and found that CCR10, HLA-DRB4, LENG8, QRFPR, and UHRF1BP1 may play key roles in obesity OA; however, we did not achieve the same results in GSE98460 database because of the limited sample size. Here, LENG8 is linked to obesity due to melanocortin 4 receptor deficiency.