Pathophysiological studies have shown that kidney function damage caused by DM is mainly in three aspects: perfusion level, oxygenation level, and water molecule dispersion movement; and BOLD-MRI can use deoxygenated hemoglobin (Hb) as an endogenous contrast agent, which can effectively assess the oxygenation level of the tissue. The gene discussed is GSTM1; the disease is diabetes mellitus.