Human genetics studies show that inactivating mutations in the ANGPTL4 gene (E40K) improve glucose and lipid homeostasis and reduce the risk of coronary artery disease and diabetes (Dewey et al., 2016; Stitziel et al., 2016; Liu D. J. et al., 2017; Gusarova et al., 2018). The gene discussed is ANGPTL4; the disease is coronary artery disorder.