Overexpression of one or more tumor suppressor genes can effectively inhibit the growth and progression of tumors, among which protein 53 (p53)gene and phosphatase and tensin homolog (PTEN)gene are the most classical and the most deeply studied (Lee and Muller, 2010; Álvarez-Garcia et al., 2019; Lacroix et al., 2020). This evidence concerns the gene PTEN and neoplasm.