A study reported that in vivo delivery of the TK-p53- nitroreductase triple therapeutic gene by poly (D,L-lactic-co-glycolic acid)-poly (ethylene glycol)-Polyethylenimine NPs functionalized with SP94 peptide (a peptide that targets hepatocytes) restored p53 function and enhanced cancer cells’ response to the prodrug ganximation glycoxyguanosine and CB 1954 (Sukumar et al., 2020). Here, TP53 is linked to cancer.