PDIA3 and colorectal cancer: Figure 1 specifically, ELISA was adopted to determine the protein contents of HP and PDIA3 in the peripheral blood to identify the role and value of HP and PDIA3 in colorectal cancer screening, to establish statistics on relevant pathological characteristics, and to further verify the guiding value of the aforementioned two indicators (HP and PDIA3) in assessing colorectal cancer staging.