In particular, EGCG mediated multiple signaling pathways to inhibit cell proliferation, migration, and invasion, thus limiting tumor progression, which included PI3K, Akt, NF-κB, MAPK, Wnt (Pianetti et al., 2002; Pan et al., 2007) and estrogen receptor (Belguise et al., 2007; Li et al., 2010) signaling pathways. Here, AKT1 is linked to neoplasm.