HIF1A and neoplasm: Furthermore, green tea catechins suppressed invasion and migration by TIMPs and MMPs(Deb et al., 2019; Fan et al., 2021); inhibited tumor angiogenesis by downregulating IGF-1 (Harper et al., 2007), HIF1α (Thomas and Kim, 2005) and VEGF (Roomi et al., 2015b); and targets NK-κB (Saedmocheshi et al., 2019), COX-2 (Adhami et al., 2007), interleukin family (Mukherjee et al., 2014), androgen receptor (Stanislawska et al., 2019) to suppress prostate cancer cell growth.