Toward endometrial cancer, the effect of the prodrug of EGCG (ProEGCG) exhibited anti-proliferative, pro-apoptotic, and anti-tumor actions via ERK/JNK, Akt and PI3K/AKT/mTOR/HIF1α signaling pathway (Wang Q. et al., 2018; Man et al., 2020). Here, MAPK8 is linked to endometrial cancer.