AKT1 and kidney disorder: The conclusion that these circRNAs in our study may be potential targets for the treatment of kidney disease is based on reasonable analogies to existing studies, such as the finding that ciRS-7 is highly expressed in renal cell carcinoma tumor tissues and cell lines and may serve as a prognostic marker, and further evidence that ciRS-7 acts as a “ceRNA” for miR-139-3p, preventing TAGLN degradation and promoting the development and metastasis of renal cell carcinoma through the PI3K/AKT signaling pathway [39].