In the meantime, another double-blind, randomized clinical study on prediabetic, vitamin D-deficient human subjects revealed significant improvement in insulin sensitivity and reduced progression toward overt DM following six (6)-month treatment with oral vitamin D3 (50,000 IU), weekly for three (3) months, followed by once-a-month treatment for the next three (3) months [63]. The gene discussed is INS; the disease is diabetes mellitus.