Interestingly, observations in HEK293 cells and MDCK cells also indicate that Merlin, the protein encoded by the neurofibromatosis type 2 (NF2) tumor suppressor gene and a regulator of Hippo signalling (Zheng and Pan, 2019), is part of the Amot—PATJ—Pals1 complex and directly interacts with Amot in a competitive manner with Rich1 to regulate Rac1 activity (Yi et al., 2011). This evidence concerns the gene NF2 and neoplasm.