Mortalin sequesters p53 in the cytosol of cancer cells and inhibits its translocation to the nucleus, thus hampering several functions of p53, including transcriptional activation, centrosome duplication, and apoptosis in cancer cells (Wadhwa et al., 1998; Ma et al., 2006; Lu et al., 2011a; Lu et al., 2011b; Yang et al., 2011). The gene discussed is HSPA9; the disease is cancer.