In view of having effective treatment and early diagnosis in the field of neurodegeneration, several advances have been made in the past three decades and as a result, Tau protein, α-synuclein, DJ-1, and beta-amyloid in cerebrospinal fluid (CSF) and blood have been identified as potential diagnostic biomarkers for PD (Hong et al., 2010; Parnetti et al., 2013). This evidence concerns the gene PARK7 and Parkinson disease.