There is indisputable evidence for Parkin, PTEN-induced kinase 1 (PINK1), and DJ-1 mutation in PD patients, and other genes also involved in mitochondrial functions are also closely linked to controlling mitochondrial quality and providing an important connection to neurodegeneration (Cookson, 2012; Bonnet et al., 2012; Savitt et al., 2006). This evidence concerns the gene PRKN and Parkinson disease.