FTO and ovarian carcinoma: In this study, ectopic expression of FTO in ovarian cancer cells inhibited the m6A level in the 3′UTR of two phosphodiesterase genes, PDE1C and PDE4B, and reduced their mRNA stability, leading to activation of second messenger 3′, 5′-cyclic adenosine monophosphate (cAMP) signaling and suppression of stemness features (Huang et al., 2020).