NANOG and breast carcinoma: In response to hypoxia, hypoxia-inducible factor (HIF)-1α and HIF-2α were stimulated to promote ALKBH5 expression in breast cancer cells; subsequently, ALKBH5 inhibited the m6A level in the 3′UTR of Nanog mRNA and increased NANOG expression, resulting in enhanced breast cancer stem cell phenotype (Zhang et al., 2016).