Our team recently identified the novel oncogenic epitranscriptome axis of METTL3-m6A-GLUT1-mTORC1 (Chen et al., 2021) and YTHDF1-m6A-ARHGEF2 (Wang et al., 2022) in promoting CRC tumorigenesis. This evidence concerns the gene YTHDF1 and colorectal carcinoma.