In response to hypoxia, hypoxia-inducible factor (HIF)-1α and HIF-2α were stimulated to promote ALKBH5 expression in breast cancer cells; subsequently, ALKBH5 inhibited the m6A level in the 3′UTR of Nanog mRNA and increased NANOG expression, resulting in enhanced breast cancer stem cell phenotype (Zhang et al., 2016). Here, EPAS1 is linked to breast cancer.