ARHGEF2 and colorectal carcinoma: As to the latter study, knockdown of YTHDF1 suppressed CRC organoids and decreased cell growth; mechanistically, YTHDF1 bind to m6A marks of ARHGEF2 mRNA and enhanced ARHGEF2 translation by multiomic analysis of m6A sequencing, RNA sequencing, YTHDF1 RNA immunoprecipitation sequencing and proteomics (Wang et al., 2022).