In patients with breast cancer, ACD of fast-cycling cancer cells produced slow-cycling G0-like progenies that are AKTlowRoslowHes1hi, in a process that is dependent on the asymmetric inhibition of AKT/PKB kinase signals in the two daughter cells at the end of mitosis (Dey-Guha et al., 2011). Here, AKT1 is linked to breast carcinoma.