Administration of losartan increases RBF, but 2K1C induced hypertension possibly by a decrease of AT1R expression, as well as, reduce activation of ACE2/MasR pathway, and supraphysiological doses of estrogen to promote the vasoconstrictor actions of AT2R with an unknown mechanism could increase RBF and RVR responses to Ang II infusion. The gene discussed is ACE2; the disease is hypertensive disorder.