MAS1L and Hypertension: Administration of losartan increases RBF, but 2K1C induced hypertension possibly by a decrease of AT1R expression, as well as, reduce activation of ACE2/MasR pathway, and supraphysiological doses of estrogen to promote the vasoconstrictor actions of AT2R with an unknown mechanism could increase RBF and RVR responses to Ang II infusion.