HIF1A and pulmonary arterial hypertension: As a result, the AUC values of ten hub genes for PAH exceeded 0.8 in the GSE113439 dataset (Figure 7), which verifies the diagnostic value of hub genes (HSP90AA1, HIF1A, MET, IGF1, LRRK2, CLTC, DNM1L, MDM2, RICTOR, and ROCK2) in PAH and indicates these hub genes may play a vital role in PAH pathogenesis.