The pro-cancer and anti-cancer functions of miR-100-5p have been shown from cancers of numerous origins, for example, miR-100-5p is lowly expressed in prostate cancer, which impairs cancer cell proliferation, migration, and invasion via downregulating mTOR [19]; in contrast, overexpression of miR-100-5p is observed in ovary cancer, which promotes cell invasion via directly targeting SMARCD1 [20]. Here, SMARCD1 is linked to Familial prostate cancer.