FZD8 and Familial prostate cancer: Afterwards, overexpression of FZD8 was observed in TPC-1 and KTC-1 compared to Nthy-ori3-1, indicating the oncogenic role of FZD8 in PTC, which was in consistent with the function of FZD8 in other cancer types, including prostate cancer [23], non-small cell lung cancer [24], and head and neck squamous carcinomas [25].