However, no difference was found in the promoter methylation level of SAE1 between tumor and normal livers (Figure 7b, P = 0.9077600), and only a weak negative correlation was observed between the DNA methylation level of SAE1 and the transcriptional level of the gene (Figure A2a, r = –0.14, P = 0.006). This evidence concerns the gene SAE1 and neoplasm.