The FnBPA antibody also significantly decreased the activation of the c-fos and NF-κB caused by MRSA (Figure 3f) indicating that MRSA upregulated the fnbpA to activate TLR4/NF-κB/p38 MAPK/c-fos signaling pathway and then to increase the proliferation of tumor cells. Here, TLR4 is linked to neoplasm.