Different from the FnBPB on host epithelium cells, we found that highly expressed fnbpA in MRSA was able to activate the downstream TLR4/NF-κB/p38 MAPK/c-fos pathway, then promoting the proliferation of squamous cell carcinoma, indicating the different actions of FnBPA on cancer cells. The gene discussed is NFKB1; the disease is squamous cell carcinoma.