MTOR and cancer: According to HALLMARK gene sets defined by MSigDB, high BUB1 subtype was significantly enriched in “G2/M checkpoint,” “DNA repair,” “cell cycle,” “DNA replication,” and “WNT/MYC/NORCH/HEDGEHOG/mTOR signaling pathway,” which were established hallmarks and pathways associated with cancer cell proliferation and stemness (Figures 3(m) and 3(n)).