AKT1 and cancer: GSVA analysis identified that most cancer hallmarks, including G2M checkpoint, E2F targets, DNA repair, MYC pathway, glycolysis pathway, PI3K-AKT-mTOR pathway, EMT, hypoxia, and angiogenesis were significantly enriched in the RMScore-high group (Figure 4(c)), which was similar to that in RNA modification Cluster B. However, the immune score in the RMScore-high group was significantly lower than that in the RMScore-low group (Figure 4(d)), which implied that the RMScore-low group was more related to TME-associated immune cells.