CD4 and cancer: GSVA and ssGSEA analysis showed that most cancer hallmarks, including TGF-βsignaling pathway, KRAS signaling pathway, hypoxia, EMT, and androgen response pathway, were enriched in BRCA patients in Cluster B (Figure S7B), while most immune cells, including activated B cells, activated CD4 and CD8 cells, dendritic cells, macrophage, and monocytes were enriched in BRCA patients in Cluster A (Figure S7C).