IRF1 and breast cancer: To investigate the role of IRF1 in cell death induced by SBP-0636457/Dox, siRNAs against IRF1 were used in BC cells (Figure 3(g)), and it was found that IRF1 silencing markedly reduced cell death induced by SBP-0636457/Dox/z.VAD in BC cells (Figure 3(h)).