AVP and chronic obstructive pulmonary disease: Another study found that increased copeptin concentrations predicted mortality in acute HF (HR = 1.61) and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) (HR = 1.72), and copeptin reclassified a significant proportion of patients into a more accurate risk stratification in acute HF [0.39 (95% CI 0.06–0.71)] and AECOPD [NRI 0.60 (95% CI 0.19–1.02)] (135).