Furthermore, in a prospective cohort study, copeptin was reported to improve the prognostic ability of the ABCD2 score for the prediction of IS in 31.2% of patients (223), requiring further studies to validate whether the addition of copeptin to the ABCD2 score can help refine the management of patients with the transient ischemic attack (TIA) and reduce healthcare costs. The gene discussed is AVP; the disease is transient ischemic attack.