More interestingly, activation of RORα can in feedback increase the level of MaR1 through transcriptional induction of 12-LOX, the key enzyme in MaR1 biosynthesis, thus reestablishing the MaR1/RORα/12-LOX autoregulatory circuit may provide a potential therapeutic strategy for treating NASH (20). Here, ALOX12 is linked to metabolic dysfunction-associated steatohepatitis.