Additionally, the sarcomeric proteins titin (TTN) contains over 7,000 VUS implicated in 25% of all inherited DCM cases and myosin-7 (MYH7) contains ~1500 VUS associated with HCM and RCM (Figures 1A, 2A) (99). Here, TTN is linked to cardiomyopathy, familial restrictive, 1.