IRS2 and neoplasm: The results showed that the transcriptional expression levels of NDRG1 (P < 0.001), ERRFI1 (P < 0.001), IRS2 (P < 0.001), IGFBP4 (P < 0.01), and BIRC3 (P < 0.01) were significantly decreased in tumor tissues, while SOCS1 (P < 0.05) expression was increased (Figure 8A–8F).