SKP2 and cancer: Some DEGs with high topological parameters were defined as hub genes, including genes that play important roles in cell cycle arrest in senescence (CDK6, CDKN1A) [26], genes that are key targets of cancer therapy (PIM1, SKP2) [27, 28], genes related to the tumor microenvironment (CXCL8) [29], and genes that encode tumor suppressors (SOCS1) [30].